University Of Pittsburgh School Of Medicine Researcher Discovers How Coronavirus Causes Harmful Inflammation

PITTSBURGH (KDKA) — A researcher at the University of Pittsburgh School of Medicine has discovered how coronavirus can cause harmful and escalating inflammation.

It is because of a region on the spike protein she calls a superantigen.

“That region would be expected to trigger a very strong response, adaptive immune response, and now the response is so exaggerated,” says Ivet Bahar, Ph.D., distinguished professor and John K. Vries Chair of computational and systems biology at Pitt School of Medicine.

Her work came about by trying to get a better handle on what happens in the severe pediatric coronavirus-related illness MIS-C or multisystem inflammatory syndrome in children. The symptoms of low blood pressure, fever and rash looked very similar to toxic shock syndrome, a potentially fatal illness caused by bacterial toxins.



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By using computer models, she found a surprise.

“We started to

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California First U.S. State to Ban Harmful Cosmetics Ingredients, Already Forbidden in the EU

California is the first state in the nation to ban 24 toxic ingredients from being used in cosmetics, after Gov. Gavin Newsom signed Assembly Bill 2762, the Toxic-Free Cosmetics Act, on Wednesday. The law will take effect starting on Jan. 1, 2025.

The harmful ingredients, which are connected to a number of major health-related issues, birth defects and diseases including cancer, are already forbidden from beauty and personal-care products sold in 40 countries, including the European Union.

“Children, communities of color and pregnant women are especially vulnerable to these ingredients, which are not actively regulated by the federal government,” Newsom said in a statement.

Authored by Assembly members Al Muratsuchi, Bill Quirk and Buffy Wicks, the list of banned chemicals includes PFAS (per- and polyfluoroalkyl substances), mercury, formaldehyde, along with endocrine-disrupting phthalates and long-chain parabens, which are preservatives used in skin-care products.

“For more than 80 years, Congress has neglected

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Intensive Blood Pressure Lowering Potentially Harmful in ICH

Intensive lowering of systolic blood pressure (SBP) for patients with intracerebral hemorrhage (ICH) whose initial SBP is excessively high does not improve outcomes and is linked to safety concerns, new research shows.

Investigators found that ICH patients whose initial SBP was 220 mmHg and who underwent intensive BP lowering had twice the relative risk for neurologic deterioration at 24 hours without any reduction in hematoma expansion or 3-month risk for death and disability compared to their counterparts who underwent standard SBP lowering.

“The significantly higher rate of neurological deterioration associated with intensive treatment in patients with initial systolic blood pressure of 220 mm Hg or more warrants caution against broad recommendations for intensive systolic blood pressure reduction in patients with intracerebral hemorrhage,” the investigators, led by Iryna Lobanova, MD, Zeenat Qureshi Stroke Institute, University of Missouri, in Columbia, write.

The study was published online September 8 in JAMA Neurology.

Efficacy

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Trump’s attack on Hunter Biden underscores ‘harmful stigma’ of addiction

Remarks like these perpetuate “a harmful stigma,” said Mark Sutton, spokesman for the nonprofit Drug Policy Alliance, which advocates for the decriminalization of drug use.

“At a time when we have approximately 70,000 people in the United States dying per year from accidental overdose, it is unconscionable that someone vying for our highest elected office would be so willing to throw people struggling with substance-use disorder under the bus,” he added.

Federal data shows that roughly 1 in 10 American adults — or 23 million people — have struggled with a drug-use disorder at some point in their lives. Such a diagnosis is “based on a list of symptoms including craving, withdrawal, lack of control, and negative effects on personal and professional responsibilities,” according to the National Institutes of Health. Drug abuse is not necessarily illicit — many people addicted to opioids obtain them legally through a doctor’s prescription, for

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