Vericiguat Benefits Even With High Adherence to HFrEF Meds

Vericiguat (Merck/Bayer), among the latest drugs to gain cred in heart failure (HF) with reduced ejection fraction (HFrEF), significantly benefits patients who are highly adherent to standard-of-care (SOC) HF meds, suggests a new VICTORIA trial analysis.

The novel agent seemed to improve the primary endpoint on top of the entire slate of SOC agents, individually and when they were combined as guidelines recommend.

The research, reported earlier this week at the Heart Failure Society of America (HFSA) Virtual Annual Scientific Meeting 2020, also hinted at potential clinical-outcomes synergy between vericiguat and a drug class that is a cornerstone of HF medical management.

The findings argue against misgivings that recent and any future additions to the HF armamentarium could be therapeutically redundant or add to patients’ daily pill burden and potential for side effects without much incremental benefit.

There is as yet little evidence for such an effect; also, vericiguat and

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Stress Associated With HFpEF but Not HFrEF?

Stress was linked to higher long-term risk related to heart failure with preserved ejection fraction (HFpEF), researchers found from the large REGARDS cohort.

People who reported feeling more stress had more incident HFpEF-related death and hospitalization over a median follow-up of 10.1 years compared with peers scoring zero on the Perceived Stress Scale (PSS) assessment:

  • PSS score 1-2: adjusted HR 1.37 (95% CI 1.00-1.89)
  • PSS 3-4: adjusted HR 1.42 (95% CI 1.04-1.95)
  • PSS ≥5: adjusted HR 1.41 (95% CI 1.04-1.92)

In contrast, stress had no discernable relationship with incident HFrEF events, reported Lauren Balkan, MD, of Weill Cornell Medical Center in New York City, during her presentation at a moderated poster session at this year’s virtual conference of the Heart Failure Society of America.

HFpEF is thought to be a progressive systemic disorder influenced by aging and key comorbidities, such as chronic kidney disease and obesity. It is possible that

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