Phase 2b/3 Trial Shows Efficacy of Filgotinib for the Induction and Maintenance of Remission in Moderately and Severely Active Ulcerative Colitis

— Filgotinib 200mg Achieved Endoscopic, Histologic and Six-Month Corticosteroid-Free Remission at Week 58 with a Consistent Safety Profile —

— Study Enrolled Biologic-Na├»ve and Biologic-Experienced Patients, a High Proportion of Whom Were Highly Refractory —

Gilead Sciences, Inc. (Nasdaq: GILD) and Galapagos NV (Euronext & Nasdaq: GLPG) today presented late-breaking data demonstrating sustained efficacy and safety with filgotinib, an investigational, oral, once-daily, JAK1 preferential inhibitor, for the treatment of moderately to severely active ulcerative colitis (UC). The data from the randomized, double-blind, placebo-controlled, Phase 2b/3 SELECTION trial showed that a significantly higher proportion of patients treated with filgotinib 200 mg, versus placebo, achieved clinical remission at Week 10 and maintained remission through Week 58. In addition, significantly more patients achieved six-month corticosteroid-free remission. The full results were presented today at the 2020 United European Gastroenterology Week (UEGW) Virtual Meeting (Abstracts #LB19 and #LB20).

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CME: Maintenance of Certification on Family Medicine

The maintenance of certification program for family physicians is something that allows the American Board of Family Medicine (ABFM) to maintain the competency of their professionals. The American Board of Medical Specialties (ABMS) – in which ABFM is a member – felt a growing threat from outside the medical industry requiring them to continually strive for excellence. In response to that challenge, ABMS started the MOC program. The program is designed to push their specialists to continually educate themselves even after medical school. To make things more interesting, ABMS started issuing time-limited certificates; that way, their specialists will be left with no choice but to engage in the MOC program and in CME activities.

Like most specialty board members of ABMS, the family medicine MOC program is divided in to four categories; each category must be successfully completed before re-certification is assured. The categories are: professionalism, self-assessment and lifelong learning, … Read More

Fitness Is About Health and Staying Healthy Is About Good Body Maintenance

Some are born with an inbuilt knowledge of what one’s body needs. Others are easily misguided and led by fashion, popularity, and peer pressure into things that should be avoided. There is also the bodies willingness or otherwise to partake of harmful substances. In my case my body could not tolerate chemicals or anything that affected the brain. This was guided by my keen desire for knowledge and making my intelligence number one.

The lessons learned are that what we do when we are young has an impact on aging and on what diseases and handicaps we will face as the years pile up. Good body maintenance is about avoiding anything toxic and that includes even dangerous rides at carnivals.

The latest fad is to take rides on vehicles that cause a drop and sudden stop, as in some crazy fairground roller coaster adventures. Watching one of these recently it … Read More